This unit provides trainees with an overview of safety considerations for nearly every aspect of laboratory operation. Safety issues regarding lab design and how design features protect lab workers are discussed. The importance of ventilation and the operation of ventilating equipment (such as chemical hoods and biological safety cabinets) are also emphasized. Also detailed are safe practices and precautions associated with the handling and storage of chemicals. The unit also describes various methods for cleaning up chemical spills and the procedures and regulatory concerns for disposing of chemical waste.